Congratulations to Drs. Chenge Mahomva, Kristine Smith, and co-authors Prince Minkah and Drs. Ben Witt, Gretchen Oakley, Richard Orlandi, Jeremiah Alt, and Abby Pulsipher, for publishing their manuscript, “Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis,” in the Journal of Inflammation Research (May 2024). CCL19 can exert both pro- and anti-inflammatory effects through interactions with its typical (CCR7) and atypical (CCRL1) receptors and has been shown to predict disease severity in COVID-19 and treatment response in rheumatoid arthritis. Its role in Chronic rhinosinusitis (CRS) remains unknown. Their study sought to determine the transcriptional changes in CCL19, its receptors, and associated cytokines and their association with disease severity in CRS.
